Taurine TransportInhibitorySubstance in Sesame Seeds
نویسنده
چکیده
An ethanol extract from sesame seeds inhibited the taurine uptake in human intestina) epithelial Caco-2 cells. The uptake of such a-amino acids as leucine and glutamic acid was not jnhibited by the extract, indicating that this inhibition is speeific to the taurine uptake. The llnknown inhibitor in the sesame extract was purjfied by reversed-phase HPLC by monitoring the inhibitory elkct on taurine uptake. The iselated substance was identified as lysophosphatidylcholine, tino}eoyl (Lyso-PC), by NMR aild MS ana]ysis. Lyso-PC inhibited the taurine uptake in a dose-dependent manner with an ICso yalue of approximately 200 ptM. Although LysoPC is known to be a surface active and cell lytic com-
منابع مشابه
Comparative effects of sesame seeds differing in lignan contents and composition on fatty acid oxidation in rat liver.
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